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Compound 15a (Wang et al., 2020): Exhibits potent NNMT inhibition (IC5 2 ~30 nM) with promising efficacy in murine metabolic disorder models

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A new formulation patent that extends exclusivity by 3 years on a drug generating $2 billion annually is worth roughly $4-6 billion in present value, depending on the discount rate and the probability that the patent survives a challenge